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PHARMACEUTICAL ANALYSIS

Flow Injection Chemiluminescence Determination of Cephalosporin Antibiotics by Their Enhancing Effects on Luminol–Potassium Periodate System

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Pages 2975-2983 | Received 17 Apr 2003, Accepted 21 Jul 2003, Published online: 02 Feb 2007
 

Abstract

It was found that the chemiluminescence arising from the reaction of luminol with KIO4 in alkaline solution could be strongly enhanced by cephalosporin antibiotics. Based on these observations, a new flow injection chemiluminescence method is proposed for the determination of four cephalosporin antibiotics: cefalexin, cefaclor, cefradine, and cefadroxil. The detection limits of the method are 0.9 ng mL−1 cefalexin, 0.4 ng mL−1 cefaclor, 10 ng mL−1 cefradine, and 10 ng mL−1 cefadroxil. The method was successfully applied to the determination of four cephalosprin antibiotics in pharmaceutical preparations.

Acknowledgment

This work was financially supported by Xi'an Jiaotong University.

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