Differential Pulse Voltammetry for Determination of Benorilate in Pharmaceutical Formulations at Carbon Paste Electrode

Abstract

Benorilate was determined by the differential pulse voltammetry (DPV) using a carbon paste electrode in 1.25×10⁻³ mol·l⁻¹ KH₂PO₄ and Na₂HPO₄ buffer solution (pH=6.88, 25°C). The anodic peak potential was +1.020 V (versus saturated calomel electrode (SCE)). A good linear relationship was realized between the anodic peak currents and benorilate concentrations in the range of 2.0×10⁻⁷ to 4.5×10⁻⁴ mol·l⁻¹ with the detection limit of 5.0×10⁻⁸ mol·l⁻¹. The recovery was 94.3 to 104.6% with the relative standard deviation of 3.5% (n=9). The pharmaceutical preparations, benorilate tablets samples, were determined with desirable results.

This work was supported by the National Natural Science Foundation of China (No. 20175023, 20375034), and the Natural Science Foundation of Jiangsu Provincial Education Department (No. 02KJB150013).

Keywords:

• Benorilate
• carbon paste electrode
• differential pulse voltammetry
• pharmaceutical analysis

Notes

This work was supported by the National Natural Science Foundation of China (No. 20175023, 20375034), and the Natural Science Foundation of Jiangsu Provincial Education Department (No. 02KJB150013).