A SONOCHEMICAL PROTOCOL FOR THE SYNTHESIS OF PERMODIFIED CYCLODEXTRINS[1]

Abstract

A series of O-peralkylated β- and γ-cyclodextrins, commonly used as stationary phases in high-resolution gas chromatography or as drug carriers, has been prepared both according to the usual methods and with sonocatalysis. The sonochemical protocol, using either a common cleaning bath or sonochemical apparatus, resulted in markedly improved yields, reaction times and reproducibility.

ACKNOWLEDGMENTS

We are thankful to Professor P. Savarino of the Dipartimento di Chimica Generale ed Organica Applicata for the use of sonochemical apparatus, and to Professor C. Bicchi of our Department for the GC tests.

This work was supported by M.U.R.S.T. (Progetto: Chimica dei Composti Organici di Interesse Biologico, Fondi ex 40%).