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Abstract
This study was designed to determine whether an improvement in cardiovascular risk factors persists in spontaneously hypertensive rats (SHR) following withdrawal of angiotensin converting enzyme inhibitor (ACE-I) treatment. SHR were given deionized drinking water or captopril solution from four to sixteen weeks of age. At twelve weeks of age, rats from each group were instrumented with radiotelemetry devices for continuous monitoring of blood pressure. Mean arterial blood pressure was significantly lower in captopril-treated SHR during treatment (92±2 vs 147±1 mm Hg), and at twelve weeks after treatment withdrawal (131±2 vs 158±2 mm Hg). In addition, proteinuria, renal vascular resistance, plasma triglyceride levels, fasting glucose levels, postprandial insulin levels, and heart weights were significantly reduced in the treated SHR compared to control SHR, at time-points between three to seven months after captopril withdrawal. Our findings indicate that short-term administration of an ACE-I during the developmental phase of hypertension in the SHR results in a long-term overall improvement of cardiovascular risk factors.
| LIST OF ABBREVIATIONS | ||
| SHR | = | spontaneously hypertensive rat |
| ACE-I | = | angiotensin converting enzyme inhibitor |
| MABP | = | mean arterial blood pressure |
| SBP | = | systolic blood pressure |
| DBP | = | diastolic blood pressure |
| HR | = | heart rate |
| RBF | = | renal blood flow |
| RVR | = | renal vascular resistance |
| GFR | = | glomerular filtration rate |
| UV | = | urine volume |
| UNaV | = | urinary sodium excretion rate |
| UKV | = | urinary potassium excretion rate |
| UPROTV | = | urinary protein excretion rate |
| UCREATV | = | urinary creatinine excretion rate |
| UPROT/CREAT | = | ratio of urinary protein to creatinine |
| CLCR | = | creatinine clearance |
| LIST OF ABBREVIATIONS | ||
| SHR | = | spontaneously hypertensive rat |
| ACE-I | = | angiotensin converting enzyme inhibitor |
| MABP | = | mean arterial blood pressure |
| SBP | = | systolic blood pressure |
| DBP | = | diastolic blood pressure |
| HR | = | heart rate |
| RBF | = | renal blood flow |
| RVR | = | renal vascular resistance |
| GFR | = | glomerular filtration rate |
| UV | = | urine volume |
| UNaV | = | urinary sodium excretion rate |
| UKV | = | urinary potassium excretion rate |
| UPROTV | = | urinary protein excretion rate |
| UCREATV | = | urinary creatinine excretion rate |
| UPROT/CREAT | = | ratio of urinary protein to creatinine |
| CLCR | = | creatinine clearance |