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Original Articles

Detection of Organophosphates Using an Acetyl Cholinesterase (AChE) Coated Microcantilever

, , , &
Pages 175-183 | Received 19 Aug 2003, Accepted 30 Sep 2003, Published online: 18 Aug 2006
 

Abstract

A microcantilever modified with a layer of acetyl cholinesterase (AChE) responding to paraoxon is reported in this work. Acetyl cholinesterase was immobilized on a microcantilever through a cross linker to a monolayer on gold surface of the microcantilever. The microcantilever underwent a maximum of 7 nm bending due to the inhibition of AChE by paraoxon that slightly changed the conformation of AChE.

Acknowledgments

This work was supported by the Board of Regents Support Fund under contract number LEQSF(2001‐04)‐RD‐A‐16, the Center for Entrepreneurship and Information Technology (CEnIT), Research Seed Grant of LaTech, and US Department of Energy (DOE), Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences, Environmental Remediation Science Division, Office of Biological & Environmental Research, under contract No. DE‐AC05‐00OR22725 with Oak Ridge National Laboratory, managed and operated for DOE by UT‐Battelle, LLC.

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