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Instrumentation Science & Technology Volume 32, 2004 - Issue 4
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Original Articles

Enantioselective, Potentiometric Membrane Electrode, Based on Vancomycin as Chiral Selector, for the Assay of S‐Perindopril

Kenneth I. Ozoemena Department of Chemistry, University of Pretoria, Pretoria, 0002, South Africa
,
Raluca‐Ioana Stefan Department of Chemistry, University of Pretoria, Pretoria, 0002, South AfricaCorrespondence[email protected]
,
Jacobus F. van Staden Department of Chemistry, University of Pretoria, Pretoria, 0002, South Africa
&
Hassan Y. Aboul‐Enein Pharmaceutical Analysis and Drug Development Laboratory, Biological and Medical Research Department (MBC‐03‐65), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Pages 371-378 | Received 12 Nov 2003, Accepted 15 Jan 2004, Published online: 01 Dec 2008
 
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Abstract

The construction of an enantioselective, potentiometric membrane electrode (EPME) based on carbon paste impregnated with macrocyclic antibiotic vancomycin (VCM) as chiral selector is described. The proposed electrode was applied for the assay of S‐perindopril (S‐Pdp) raw material and from its pharmaceutical formulation (Coversyl® tablets) by use of a direct potentiometric method. The surfaces of the electrode can easily be renewed by simply polishing on an alumina paper.

Acknowledgments

The authors thank Claude Harris Leon Foundation and the National Research Foundation (NRF) of South Africa for their financial support.

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