Advanced search
Publication Cover
Journal of Toxicology: Clinical Toxicology Volume 42, 2004 - Issue 1
Journal homepage
107
Views
12
CrossRef citations to date
0
Altmetric
Research Article

A Simple, Safe, and Efficient Way to Treat Severe Fluoride Poisoning—Oral Calcium or Magnesium

Wei‐Fong Kao Department of Emergency Medicine, Veterans General Hospital, 201, Shih‐Pai Road, Section 2, Taipei, Taiwan, R.O.C.; National Yang‐Ming University, Taipei, Taiwan, R.O.C.; Tzu‐Chi Buddhist University, Hualien, Taiwan, R.O.C.
, M.D.,
Jou‐Fang Deng Section of Clinical Toxicology, Veterans General Hospital, 201, Shih‐Pai Road, Section 2, Taipei, Taiwan, R.O.C.; National Yang‐Ming University, Taipei, Taiwan, R.O.C.
,
Shu‐Chiung Chiang Department of Education and Research, Veterans General Hospital, 201, Shih‐Pai Road, Section 2, Taipei, Taiwan, R.O.C.; National Yang‐Ming University, Taipei, Taiwan, R.O.C.
,
Kennon Heard Division of Emergency Medicine, University of Colorado Health Science Center, Denver, ColoradoUSA
,
David H.T. Yen Department of Emergency Medicine, Veterans General Hospital, 201, Shih‐Pai Road, Section 2, Taipei, Taiwan, R.O.C.; National Yang‐Ming University, Taipei, Taiwan, R.O.C.
,
Mei‐Chun Lu Department of Education and Research, Veterans General Hospital, 201, Shih‐Pai Road, Section 2, Taipei, Taiwan, R.O.C.
,
Benjamin Ing‐Tiau Kuo Department of Education and Research, Veterans General Hospital, 201, Shih‐Pai Road, Section 2, Taipei, Taiwan, R.O.C.; National Yang‐Ming University, Taipei, Taiwan, R.O.C.
,
Chien‐Chun Kuo Tzu‐Chi Buddhist University, Hualien, Taiwan, R.O.C.
,
Tsung‐Yun Liu Department of Education and Research, Veterans General Hospital, 201, Shih‐Pai Road, Section 2, Taipei, Taiwan, R.O.C.; National Yang‐Ming University, Taipei, Taiwan, R.O.C.
&
Chen‐Hsen Lee Department of Emergency Medicine, Veterans General Hospital, 201, Shih‐Pai Road, Section 2, Taipei, Taiwan, R.O.C.; National Yang‐Ming University, Taipei, Taiwan, R.O.C.
 show all
Pages 33-40 | Received 28 Apr 2003, Accepted 28 Sep 2003, Published online: 15 Mar 2004
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Purpose: To examine the efficacy and safety of administration of calcium and magnesium orally and intraperitoneally to treat severe sodium fluoride intoxication. Materials and Methods: Mice were initially gavaged a lethal dose of sodium fluoride (NaF) or water. Then, mice were treated with water or varying concentrations of calcium chloride (CaCl2) or magnesium sulfate (MgSO4) via intraperitoneal (IP) route or via oral route. Mice were monitored for 24h, and the time of death was recorded. Results: IP injections of large amounts of CaCl2 or MgSO4 were dangerous. All mice gavaged with water and then treated with oral CaCl2 or MgSO4 survived and displayed normal activity during the experiment. The survival rate of mice gavaged with a lethal dose of NaF and then treated with a high dose of oral CaCl2 or MgSO4 was significantly higher than those of using low dose. Conclusion: Oral administration of a high dose of CaCl2 or MgSO4 is a simple, safe, and effective adjunctive method for treating severe oral fluoride poisoning.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,501.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.