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Clinical Toxicology Volume 43, 2005 - Issue 3
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Case Report

Aripiprazole (Abilify™) Overdose in a Child

Steven A. Seifert Nebraska Regional Poison Center, University of Nebraska Medical Center, Omaha, NebraskaUSA; Section of Emergency Medicine, Department of Surgery, University of Nebraska Medical Center, Omaha, NebraskaUSA
, F.A.C.E.P. , M.D. , F.A.C.M.T.,
Michael D. Schwartz Georgia Poison Center/Emory University Department of Emergency Medicine, Atlanta, GeorgiaUSA; Georgia Poison Center/Emory University Department of Emergency Medicine, 1600 Clifton Rd., Mailstop F-32, Atlanta, GA, 30333, USA
, M.D. &
Jerry D. Thomas Georgia Poison Center/Emory University Department of Emergency Medicine, Atlanta, GeorgiaUSA
, F.A.C.M.T. , M.D.
Pages 193-195 | Published online: 11 Aug 2009
 
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Abstract

Aripiprazole, 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl] butyloxy}-3,4-dihydro-2(1H)-quinolinone, is an atypical antipsychotic medication inaugurating the newest class of atypical antipsychotics: the partial dopamine agonist. It has a particularly long half-life of elimination and variable metabolism secondary to genetic polymorphism. We report an unintentional overdose of 195 mg (17.1 mg/kg) of aripiprazole in a 2.5 year-old child. This patient exhibited CNS depression not requiring respiratory support and without significant cardiovascular effects. CNS effects persisted for almost 2 weeks postingestion.

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