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Clinical Toxicology Volume 43, 2005 - Issue 3
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Case Report

Acute Felbamate Overdose with Crystalluria

Kathryn H. Meier California Poison Control System, Department of Clinical Pharmacy, University of California, San Francisco, California, 94143-1369, USA; California Poison Control System, Department of Clinical Pharmacy, University of California, San Francisco, CA, 94143-1369, USA
,
Kent R. Olson California Poison Control System, Department of Clinical Pharmacy, University of California, San Francisco, California, 94143-1369, USA
&
Jean L. Olson School of Medicine, Department of Clinical Pathology, University of California, San Francisco, CaliforniaUSA
Pages 189-192 | Published online: 11 Aug 2009
 
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Abstract

A 3-year-old child developed vomiting, ataxia, and crystalluria after ingestion of approximately 232 mg/kg of felbamate elixir. High-powered polarization microscopy of the urine revealed sharp, needle-like crystals. The analysis of the urine crystals showed unchanged felbamate (80.9%), monocarbamate felbamate (18.8%), and trace amounts of mercapturic acid conjugates of the metabolite 2-phenylpropenal (0.1%). The serum felbamate level 15 h after ingestion was 138 mg/L. Crystalluria and hematuria resolved with intravenous fluid therapy, and the child recovered within 24 h.

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