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Case Report

Fatal Fluoxetine Ingestion with Postmortem Blood Concentrations

, M.D., , D.A.B.A.T. , M.S. & , M.D.
Pages 277-279 | Received 26 Oct 2004, Accepted 21 Dec 2004, Published online: 07 Oct 2008
 

Abstract

A 37-year-old male ingested 12 gm of fluoxetine approximately 2 hours prior to arrival at an emergency department. The patient developed tonic-clonic seizures, which resolved with diazepam and midazolam therapy. The patient then developed profound bradycardia that progressed to ventricular fibrillation and asystole. A postmortem toxicology analysis reported a fluoxetine concentration of 4500 mcg/L and diazepam of 500 mcg/L. No other drugs were detected. We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.

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