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Cancer Investigation Volume 19, 2001 - Issue 1
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Original

Herceptin: From the Bench to the Clinic

R. Colomer
, M.D.,
L. A. Shamon Ernest O. Lawrence Berkeley National Laboratory, University of California, Berkeley, California, U.S.A.
, Ph.D.,
M. S. Tsai Ernest O. Lawrence Berkeley National Laboratory, University of California, Berkeley, California, U.S.A.
, Ph.D. &
R. Lupu Ernest O. Lawrence Berkeley National Laboratory, University of California, Berkeley, California, U.S.A.; Ernest O. Lawrence Berkeley National Laboratory, University of California, One Cyclotron Rd., Building 934, Berkeley, CA, 94720, U.S.A.
, Ph.D.
Pages 49-56 | Published online: 30 Jan 2001
 
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ABBREVIATION
muMAb 4D5=

murine monoclonal antibody 4D5

chMAb 4D5=

mouse/human chimeric antibody 4D5

rhuMAb HER2=

recombinant humanized version of monoclonal antibody anti-HER2

CDR=

complementarity-determing region

FR=

framework region

VH and VL=

variable heavy and light chains, respectively

C region=

constant region

V region=

variable region

scFv=

single-chain Fv molecules.

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