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Cancer Investigation Volume 19, 2001 - Issue 4
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Original

Mitomycin C and Cisplatin Enhanced the Antitumor Activity of p53-Expressing Adenovirus in Cervical Cancer Cells

Tian-Gui Huang Department of Obstetrics and Gynecology, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China
, Ph.D.,
Sin-Ming Ip Department of Obstetrics and Gynecology, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China
, Ph.D.,
William S. B. Yeung Department of Obstetrics and Gynecology, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China
, Ph.D. &
Hextan Y. S. Ngan Department of Obstetrics and Gynecology, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China; Department of Obstetrics and Gynecology, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China
, M.D.
Pages 360-368 | Published online: 30 Apr 2001
 
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Abstract

This study investigated the enhancedantitumor activity of Ad5-p53 in combinationwith mitomycin C (MMC) or cisplatin (DDP) in cervical cancer cell lines SiHaand C-33A. MMC and DDP inhibited the growth of SiHa and C-33A cells in a dose-dependentmanner, and the combination of MMC or DDP with Ad5-p53showed a stronger growth inhibition than those treated witheither Ad5-p53, MMC, or DDP alone. As evidencedby the formation of the ∼200 bp DNA ladder and the appearance of sub-G1peak, both MMC and DDP induced apoptosis in cervical cancer cells. Westernblot analysis of p53 showed that MMC/DDP did not induce the increase of p53protein in SiHa cells nor the increase of the cellular and nuclear p53 proteinin Ad5-p53 transfected Saos-2 cells. Takentogether, these results suggested that the combination of Ad5-p53and MMC/DDP may serve as an effective therapeutic regime forhuman cervical cancer treatment.

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