18
Views
3
CrossRef citations to date
0
Altmetric
Original

Hematopoietic Stem Cells

, M.D., , M.D. & , Ph.D.
Pages 124-138 | Published online: 22 Apr 2002
 

Abbreviations
BFU-E=

Erythrocyte Blast Forming Units

CD-…=

Cluster Designation-… (a unique cell surface epitope used for phenotyping cells)

CFU=

Colony Forming Unit (in vitro assay to culture and score for lineage directed proliferation of precursor cells)

CFU-G=

Colony Forming Unit Granulocyte Lineage

CFU-L=

Colony Forming Unit Lymphocyte Lineage

CFU-M=

Colony Forming Unit Macrophage Lineage

CFU-Meg=

Colony Forming Unit Megakaryocyte Lineage

CFU-Eo=

Colony Forming Unit Eosinophil Lineage

CFU-E=

Colony Forming Unit Erythroid Lineage

CFU-GM=

Colony Forming Unit for Granulocyte/Macrophage Lineage

CFU-GEMM=

Mixed Colony Forming Unit Granulocyte-Erythrocyte-Macrophage-Monocyte

CFU-HPP=

Colony Forming Unit with High Proliferative Potential (not lineage committed, primitive precursors)

CFU-S=

Synonym S-CFU Colony Forming Units Spleen (in vivo assay performed in mice to study HSC quality)

CFU-S8=

Spleen Colony Forming Units scored on day 8

CFU-S12=

Spleen Colony Forming Units scored on day 12

CRU=

Competitive Repopulating Unit (in vivo assay where different HSC compete for repopulation of a myeloablated mouse)

CSF=

Colony Stimulating Factors (proteins that stimulate lineage directed proliferation of precursor cells)

Flt3 Ligand=

(growth factor acting on very primitive HSC, may play a role in self maintenance and expansion of HSC)

EPO=

Erythropoietin (factor acting on mature red blood cell precursors)

G-CSF=

Granulocyte Colony Stimulating Factor (stimulates predominantly granulopoiesis with neutrophilia in vivo)

GM-CSF=

Granulocyte Macrophage Colony Stimulating Factor (broader spectrum of stimulatory action than G-CSF, stimulates neutrophil and macrophage proliferation and differentiation)

HSC=

Hematopoietic Stem Cell

IL-…=

Interleukin-…(class of at least 21 different cytokines with variable biological actions on HSC and immune cells)

LIF=

Leukemia Inhibitory Factor (factor with some stimulatory action on primitive HSC)

LTBMC=

Long Term Bone Marrow Culture (in vitro culture using either feeder cells or a cytokine cocktail to maintain HSC viability over several weeks)

LTC-IC=

Long Term Culture Initiating Cells (in vitro test to assess the quality of candidate HSC after prolonged exposure in LTBMC. Cells are assayed by their ability to form CFU)

LTRC=

Long Term Repopulating Cells (cells that can repopulate a myeloablated host for a prolonged period of time, e.g., mouse >6 months)

M-CSF=

Macrophage Colony Stimulating Factor (stimulates macrophage development)

MRA=

Marrow Repopulating Ability (the ability of HSC to reconstitute hematopoiesis of a myeloablated animal)

OSC=

Omnipotent Stem Cells (proposed to be the most primitive cell with the universal ability of self-renewal and differentiation into any mature tissue of the entire organism)

PHSC=

Pluripotent Hematopoietic Stem Cells (the most primitive cell of the blood/immune system with the ability of regenerating all blood elements throughout the lifespan of the organism)

SCF=

Stem Cell Factor (stimulating growth factor acting on very primitive HSC, may play a role in self-maintenance. Also known as mast cell growth factor, stimulates mast cell proliferation)

S-CFU=

Synonym CFU-S Colony Forming Units Spleen

TGF=

Transforming Growth Factors (α and β) (factors with both stimulating and inhibitory functions on hematopoiesis)

TPO=

Thrombopoietin (factor acting on megakaryocytic lineage)

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.