Abbreviations | ||
BFU-E | = | Erythrocyte Blast Forming Units |
CD-… | = | Cluster Designation-… (a unique cell surface epitope used for phenotyping cells) |
CFU | = | Colony Forming Unit (in vitro assay to culture and score for lineage directed proliferation of precursor cells) |
CFU-G | = | Colony Forming Unit Granulocyte Lineage |
CFU-L | = | Colony Forming Unit Lymphocyte Lineage |
CFU-M | = | Colony Forming Unit Macrophage Lineage |
CFU-Meg | = | Colony Forming Unit Megakaryocyte Lineage |
CFU-Eo | = | Colony Forming Unit Eosinophil Lineage |
CFU-E | = | Colony Forming Unit Erythroid Lineage |
CFU-GM | = | Colony Forming Unit for Granulocyte/Macrophage Lineage |
CFU-GEMM | = | Mixed Colony Forming Unit Granulocyte-Erythrocyte-Macrophage-Monocyte |
CFU-HPP | = | Colony Forming Unit with High Proliferative Potential (not lineage committed, primitive precursors) |
CFU-S | = | Synonym S-CFU Colony Forming Units Spleen (in vivo assay performed in mice to study HSC quality) |
CFU-S8 | = | Spleen Colony Forming Units scored on day 8 |
CFU-S12 | = | Spleen Colony Forming Units scored on day 12 |
CRU | = | Competitive Repopulating Unit (in vivo assay where different HSC compete for repopulation of a myeloablated mouse) |
CSF | = | Colony Stimulating Factors (proteins that stimulate lineage directed proliferation of precursor cells) |
Flt3 Ligand | = | (growth factor acting on very primitive HSC, may play a role in self maintenance and expansion of HSC) |
EPO | = | Erythropoietin (factor acting on mature red blood cell precursors) |
G-CSF | = | Granulocyte Colony Stimulating Factor (stimulates predominantly granulopoiesis with neutrophilia in vivo) |
GM-CSF | = | Granulocyte Macrophage Colony Stimulating Factor (broader spectrum of stimulatory action than G-CSF, stimulates neutrophil and macrophage proliferation and differentiation) |
HSC | = | Hematopoietic Stem Cell |
IL-… | = | Interleukin-…(class of at least 21 different cytokines with variable biological actions on HSC and immune cells) |
LIF | = | Leukemia Inhibitory Factor (factor with some stimulatory action on primitive HSC) |
LTBMC | = | Long Term Bone Marrow Culture (in vitro culture using either feeder cells or a cytokine cocktail to maintain HSC viability over several weeks) |
LTC-IC | = | Long Term Culture Initiating Cells (in vitro test to assess the quality of candidate HSC after prolonged exposure in LTBMC. Cells are assayed by their ability to form CFU) |
LTRC | = | Long Term Repopulating Cells (cells that can repopulate a myeloablated host for a prolonged period of time, e.g., mouse >6 months) |
M-CSF | = | Macrophage Colony Stimulating Factor (stimulates macrophage development) |
MRA | = | Marrow Repopulating Ability (the ability of HSC to reconstitute hematopoiesis of a myeloablated animal) |
OSC | = | Omnipotent Stem Cells (proposed to be the most primitive cell with the universal ability of self-renewal and differentiation into any mature tissue of the entire organism) |
PHSC | = | Pluripotent Hematopoietic Stem Cells (the most primitive cell of the blood/immune system with the ability of regenerating all blood elements throughout the lifespan of the organism) |
SCF | = | Stem Cell Factor (stimulating growth factor acting on very primitive HSC, may play a role in self-maintenance. Also known as mast cell growth factor, stimulates mast cell proliferation) |
S-CFU | = | Synonym CFU-S Colony Forming Units Spleen |
TGF | = | Transforming Growth Factors (α and β) (factors with both stimulating and inhibitory functions on hematopoiesis) |
TPO | = | Thrombopoietin (factor acting on megakaryocytic lineage) |