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Cancer Investigation Volume 22, 2004 - Issue 4
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Brief Clinical Report

Hepatic Arterial Infusion of Paclitaxel for Liver Metastasis from Gastric Cancer

Takeshi Tono Department of Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan
, M.D.,
Takashi Iwazawa Department of Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan
, M.D.,
Shigeo Matsui Department of Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan
, M.D.,
Hiroshi Yano Department of Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan
, M.D.,
Yutaka Kimura Department of Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan
, M.D.,
Toshiyuki Kanoh Department of Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan
, M.D.,
Tadashi Ohnishi Department of Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan
, M.D.,
Yoshiaki Nakano Department of Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan
, M.D.,
Jun Okamura Department of Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan
, M.D. &
Takushi Monden Department of Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan
, M.D. show all
Pages 550-554 | Published online: 24 Sep 2004
 
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Abstract

Little is known about hepatic arterial infusion (HAI) of paclitaxel for hepatic malignancies. The authors administered paclitaxel via the HAI port in two patients with liver metastases from gastric cancer. Both patients were uneventfully treated without any serious complications, and its anti-tumor effect on 5-fluouracil resistant liver metastases was confirmed. However, the kinetics of venous paclitaxel concentration following HAI was similar to that after intravenous injection. Our findings did not support the advantage of paclitaxel HAI therapy, although HAI of this agent was well tolerated.

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