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Cancer Investigation Volume 22, 2004 - Issue 6
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Original Article

The Relationship Between a Urinary Cachectic Factor and Weight Loss in Advanced Cancer Patients

M. L. Williams Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland, 21224-6825, USA; Department of Pharmacology, Georgetown University, 3900 Reservoir Road NW, Washington, District of Columbia, 20007, USA
,
A. Torres-Duarte Department of Pharmacology, Georgetown University, 3900 Reservoir Road NW, Washington, District of Columbia, 20007, USA
,
L. J. Brant Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland, 21224-6825, USA
,
P. Bhargava Department of Pharmacology, Georgetown University, 3900 Reservoir Road NW, Washington, District of Columbia, 20007, USA; Division of Hematology Oncology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, Massachusetts, 01655, USA
,
J. Marshall Lombardi Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road NW, Washington, District of Columbia, 20007, USA
&
Irving W. Wainer Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland, 21224-6825, USA; Department of Pharmacology, Georgetown University, 3900 Reservoir Road NW, Washington, District of Columbia, 20007, USA
, Ph.D.
Pages 866-870 | Published online: 23 Nov 2004
 
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Abstract

A 24K glycoprotein, the proteolysis-inducing factor (PIF), has been identified in mice and humans with cancer cachexia. Clinical cross-sectional studies found an association between the presence of PIF in urine and tumors of patients and weight loss. For the first time, we report results from a longitudinal study establishing the relationship between a urinary PIF pattern and persistent weight loss. Over time, cancer patients positive for the PIF pattern experienced weight loss, whereas those with a negative test gained weight.

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