Advanced search
Publication Cover
Drug and Chemical Toxicology Volume 27, 2004 - Issue 4
Submit an article Journal homepage
86
Views
12
CrossRef citations to date
0
Altmetric
Research Article

Toluene and p‐Xylene Induced LLC‐PK1 Apoptosis

Saeed S. Al‐Ghamdi Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al‐Qura University, P.O. Box 7951, Makkah, Saudi Arabia
,
Martin J. Raftery Department of Experimental Medicine and Nephrology, St. Bart's and Royal London School of Medicine and Dentistry, Queen Mary‐University of London, London, United Kingdom
&
Muhammad M. Yaqoob Department of Experimental Medicine and Nephrology, St. Bart's and Royal London School of Medicine and Dentistry, Queen Mary‐University of London, London, United Kingdom
Pages 425-432 | Published online: 26 Oct 2004
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Occupational exposure to organic solvents was found to be associated with development and progression of tubulo‐interstitial fibrosis and chronic renal failure. However, the cellular mechanism by which this occurs remains elusive. This study was conducted to evaluate the mode of cell death in proximal tubular cells exposed to organic solvents. LLC‐PK1 cell line cytotoxicity due to exposure to 1 mM of either p‐xylene or toluene was compared to untreated control by cell viability, LDH release, and DNA fragmentation. Cells were exposed to solvents for 96 hrs. Toluene and p‐xylene reduced cell viability and increased DNA fragmentation. LDH release was unchanged. These data indicates that long‐term exposure to organic solvents is associated with proximal tubule cell apoptosis, which may be the mechanism of progressive renal fibrosis and renal failure in patients with high solvent exposure.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,271.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.