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Drug Development and Industrial Pharmacy Volume 26, 2000 - Issue 7
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Research Article

Stability of Extemporaneous Norfloxacin Suspension

Prapaporn Boonme Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla90112, Thailand
,
Narubodee Phadoongsombut Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla90112, Thailand
,
Parichat Phoomborplub Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla90112, Thailand
&
Supavalee Viriyasom Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla90112, Thailand
Pages 777-779 | Published online: 06 May 2000
 
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Abstract

The stability of norfloxacin as extemporaneous suspensions compounded from two brands of film-coated tablets (formulas I and II) was studied. The vehicle consisted of tragacanth, saccharin sodium, sorbitol solution, glycerin, paraben concentrate, peppermint spirit BP, purified water, and syrup USP. The final concentration of norfloxacin in the suspensions was 20 mg/ml. Formulas I and II were chemically stable for 28 days when stored in amber glass bottles at ambient temperature; however, their physical characteristics were different.

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