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Abstract
Reversed-phase high performance liquid chromatography using an RP 18 column (4 × 125 mm), tetrahydrofuran–acetonitrile–0.5% formic acid (5:25:70, v/v/v) as mobile phase and UV detection at 254 nm enabled the simultaneous determination of thiabendazole (TZ) and mebendazole (MZ) in tablets. The method showed linearity over 4.0 to 40.0 μg TZ/ml and 6.0 to 60.0 μg MZ/ml. The correlation coefficient r was. 9999 for both TZ and MZ. The coefficient of variation (CV) was 0.59–0.80% for TZ and 0.49–0.67% for MZ. The average recovery was 100.54–101.17% for TZ and 100.35–101.13% for MZ. The excipients of the tablets did not interfere in the proposed method. The developed method is precise, accurate, and selective for the determination of both benzimidazoles analyzed.