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Drug Development and Industrial Pharmacy Volume 25, 1999 - Issue 6
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Research Article

Search for Related Substances in Market Products Containing Enalapril Maleate as the Active Principle

C. Pilatti Instituto Nacional de Medicamentos, Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (ANMAT), Buenos Aires, Argentina
,
I. Ercolano Instituto Nacional de Medicamentos, Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (ANMAT), Buenos Aires, Argentina
,
M. del C. Torre Instituto Nacional de Medicamentos, Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (ANMAT), Buenos Aires, Argentina
,
C. Chiale Instituto Nacional de Medicamentos, Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (ANMAT), Buenos Aires, Argentina
&
M. Spinetto Instituto Nacional de Medicamentos, Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (ANMAT), Buenos Aires, Argentina
Pages 807-811 | Published online: 18 May 1999
 
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Abstract

This study's main object was the determination of substances, by means of high-performance liquid chromatography (HPLC), that are related to enalapril maleate in medicinal tablets. The research was on products containing a 20 mg active principle with a 12-month Δt and on those batches near their expiration date with an enalapril maleate concentration of 10, 5, and 2.5 mg.

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