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Drug Development and Industrial Pharmacy Volume 25, 1999 - Issue 9
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Research Article

Stability and In Vitro Drug Release of Flurbiprofen-Loaded Poly-ε-Caprolactone Nanospheres

F. Lacoulonche
,
F. Gamisans Department of Pharmacy, Faculty of Pharmacy, Physicochemical Unit, Avda Juan XXIII s/n, Barcelona, 08028, Spain
,
A. Chauvet
,
M. L. García Department of Pharmacy, Faculty of Pharmacy, Physicochemical Unit, Avda Juan XXIII s/n, Barcelona, 08028, Spain
,
M. Espina Department of Pharmacy, Faculty of Pharmacy, Physicochemical Unit, Avda Juan XXIII s/n, Barcelona, 08028, Spain
&
M. A. Egea Department of Pharmacy, Faculty of Pharmacy, Physicochemical Unit, Avda Juan XXIII s/n, Barcelona, 08028, Spain
Pages 983-993 | Published online: 27 Sep 1999
 
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Abstract

The effects of temperature and two different initial pH (2.67 and 7.00) on poly-ε-caprolactone (PεCL) nanospheres loaded with flurbiprofen (FB) (aqueous suspensions) were studied to investigate their influence on the stability and physicochemical characteristics of these drug delivery systems. The drug release behavior was also studied. Release of the associated FB occurred very fast on high dilution in a buffered medium. The stability of the polymeric system depends on the temperature and the initial pH value; it is more degradable with the particles stored at 40°C with an initial pH value of 2.67.

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