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Drug Development and Industrial Pharmacy Volume 26, 2000 - Issue 12
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Research Article

Statistical Optimization of a Sustained-Release Matrix Tablet of Lobenzarit Disodium

A. Boza Department of Chemical Synthesis, Center of Pharmaceutical Chemistry, Havana, Cuba
,
Y. De la Cruz Department of Chemical Synthesis, Center of Pharmaceutical Chemistry, Havana, Cuba
,
G. Jordán Department of Chemical Synthesis, Center of Pharmaceutical Chemistry, Havana, Cuba
,
U. Jáuregui-Haza Department of Chemical Synthesis, Center of Pharmaceutical Chemistry, Havana, Cuba
,
A. Alemán
&
I. Caraballo Department of Pharmacy and Pharmaceutical Technology, University of Seville, C/ Profesor García González s/n, Seville, 41012, Spain
Pages 1303-1307 | Published online: 12 Jul 2000
 
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Abstract

The statistical optimization of sustained-release matrix tablets of lobenzarit disodium salt (LDS) was performed using the central composite experiment design 23 for three independent variables: the amount of polymer (Eudragit® RS-PO) AP, the total volume of granulation solvent VS, and the amount of filler (microcrystalline cellulose) CE. The t90% was selected as the response variable. The response surfaces were performed from a statistical mathematical model. The optimal formulation was obtained for the variables (AP = 15 mg, VS = 60 μl, and CE = 0).

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