Drug Adjuvant Interaction Study Using DSC Supported by Isothermal Method

Abstract

Extensive work has been done in the field of drug adjuvant interaction studies using differential scanning calorimetry (DSC), but conclusive interpretive techniques could not be reached since very few workers supplemented their work by conventional isothermal stability testing methods. This work compared the drug adjuvant thermogram with results obtained from isothermal stability studies and used it to reiterate the results of the drug adjuvant thermograms. In the formulation of ascorbic acid in a cosmetic preparation, the various adjuvants were tested for interactions first by the isothermal stability testing technique, which was followed by DSC scanning of the drug adjuvant. The results of the two methods were compared and correlated.

Key Words:

• Drug adjuvant interaction
• DSC