X-Ray Diffraction and Electron Microscopy in the Polymorphism Study of Ondansetron Hydrochloride

Abstract

Using different techniques, we studied the possible formation of ondansetron polymorphs. Ondansetron is a carbazol antiemetic that acts as a competitive, selective inhibitor of 5-HT₃ serotonin receptors. The polymorphs were determined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results suggest that the compounds are not true crystallographic polymorphs, but instead are the product of physical structural changes in the drug, which would be of interest pharmaceutically.

Key Words:

• Ondansetron hydrochloride
• Polymorphs
• Scanning electron microscopy
• X-ray diffraction