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Drug Development and Industrial Pharmacy Volume 30, 2004 - Issue 2
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Research Article

Validation of a Capillary Zone Electrophoresis Method for Determination of Rimantadine Hydrochloride in Rimantadin100 Tablets and the Method Application to Dissolution Test Monitoring

J. Pazourek Department of Analytical Chemistry, Faculty of Science, Masaryk University, Kotlár˘ská 2, Brno, CZ‐611 37, Czech Republic
,
A. L. Revilla Department of Analytical Chemistry, Faculty of Science, Masaryk University, Kotlár˘ská 2, Brno, CZ‐611 37, Czech Republic
,
D. Gajdošová Department of Analytical Chemistry, Faculty of Science, Masaryk University, Kotlár˘ská 2, Brno, CZ‐611 37, Czech Republic
&
J. Havel Department of Analytical Chemistry, Faculty of Science, Masaryk University, Kotlár˘ská 2, Brno, CZ‐611 37, Czech Republic
Pages 125-134 | Published online: 03 Nov 2004
 
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Abstract

A capillary zone electrophoretic method with indirect UV‐detection for determination of rimantadine, an antiviral drug against influenza A, in tablets was validated. Instrumental precision, the method precision, accuracy, calibration curve linearity, selectivity, robustness, and time stability of the sample and the standard were tested. The method was also applied to monitor dissolution tests of the tablets. The possibility of addition of an internal standard for improvement of the method precision was discussed.

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