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Journal of Dispersion Science and Technology Volume 24, 2003 - Issue 3-4
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Chemical Modification of Chitosan for Gene Delivery

In‐Kyu Park School of Agricultural Biotechnology, Seoul National University, Suwon, 441‐744, Korea
,
Tae‐Hee Kim School of Agricultural Biotechnology, Seoul National University, Suwon, 441‐744, Korea
,
Su‐Il Kim School of Agricultural Biotechnology, Seoul National University, Suwon, 441‐744, Korea
,
Toshihiro Akaike Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan
&
Chong‐Su Cho School of Agricultural Biotechnology, Seoul National University, Suwon, 441‐744, KoreaCorrespondence[email protected]
Pages 489-498 | Received 30 Nov 2002, Accepted 03 Feb 2003, Published online: 06 Feb 2007
 
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Abstract

Chitosan has been investigated as a non‐viral vector because it has several advantages such as biocompatibility, biodegradability, and low toxicity. However, low specificity and low transfection efficiency of chitosan as a DNA carrier need to be overcome prior to clinical trial. In this review paper, chemical modification of chitosan was tried in order to enhance cell specificity and transfection efficiency. Also, chemical modification of chitosan was performed to increase stability of chitosan/DNA complexes.

Acknowledgment

This work was supported by a grant of the Korean Ministry of Public Health and Welfare (02‐PJ3‐PG3‐31402‐0017).

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