ABSTRACT
In this study IGC50 (50% inhibitory growth concentration) values of 26 nitrobenzenes were determined for population growth endpoint of Tetrahymena thermophila. The toxicity order of the observed compounds has been found as follows: dinitro compounds>mononitro compounds; dichloronitrobenzenes>monochloronitrobenzenes; and meta-substituted nitrobenzenes > ortho-/para-substituted nitrobenzenes (NT, NPh, NAnis) except for the dinitrobenzenes and nitroanilines (DNB, NAn). Quantitative structure activity relationships (QSARs) were developed using log of the inverse of the IGC50 in mole liter as the dependent variable and six molecular descriptors—log P, 1 X v, I, 1 Ka, Σσ− and E LUMO as the independent variables. Through multiplicate regression analysis, one best equation was obtained:
The equation was used to estimate IGC50 for seven analogues.
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