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Hemoglobin
international journal for hemoglobin research
Volume 25, 2001 - Issue 1
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Original

HEMATOLOGICAL AND MOLECULAR ANALYSIS OF β-THALASSEMIA AND Hb LEPORE IN CAMPANIA, ITALY

Mara Ferrara Department of Pediatrics, Naples’ Second University, Naples, 80138, ItalyCorrespondence[email protected]
,
Sofia M.R. Matarese Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy
,
Matteo Francese Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy
,
Barbara Borrelli Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy
,
Lina Coppola Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy
,
Antonietta Coppola Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy
&
Luigi Esposito Department of Pediatrics, Naples’ Second University, Naples, 80138, Italy
 show all
Pages 29-34 | Received 08 Aug 2000, Accepted 22 Oct 2000, Published online: 07 Jul 2009
 
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Abstract

This epidemiological study was based on a hematological and a molecular analysis of 310 heterozygous β thalassemic and 75 carriers of Hb Lepore out of 3,000 microcythemic subjects from the Campania region of Italy. The molecular analysis of β chains and the δβ hybrid gene has shown different β chain defects, but only the Hb Lepore-Boston-Washington type in association with haplotypes I and V. The prevalence and distribution of these molecular defects in Campania show that they are linked to historical events and to the geographical characteristics of this region.

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