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Hemoglobin
international journal for hemoglobin research
Volume 29, 2005 - Issue 2
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Short Communication

Hb Kurosaki [α7(A5)Lys → Glu (AAG →GAG)]: An α2-Globin Gene Mutation Found in Thailand

Lukana Ngiwsara Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand
,
Chantragan Srisomsap Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand
,
Pranee Winichagoon Thalassemia Research Center, Institute of Science and Technology for Research and Development, Mahidol University, Nakornpathom, 73170, Thailand
,
Suthat Fucharoen Thalassemia Research Center, Institute of Science and Technology for Research and Development, Mahidol University, Nakornpathom, 73170, Thailand
,
Bussara Sae-Ngow Division of Hematology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand
&
Jisnuson Svasti Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, 10400, ThailandCorrespondence[email protected]
Pages 155-159 | Received 30 Oct 2004, Accepted 01 Dec 2004, Published online: 07 Jul 2009
 
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Abstract

Hb Kurosaki [α7(A5)Lys → Glu (AAG →GAG)], has been found for the first time in Thailand. The 30-year-old Thai male had a normal hematological profile at the steady state, but showed an abnormal hemoglobin (Hb) present at a level of 28%. Protein characterization was performed by automated sequencer analysis of the abnormal α-globin chain and amino acid analysis of the abnormal αT-1,2 peptide. Direct DNA sequence analysis of selectively amplified segments of the α1 and α2 genes showed that codon 7 of the α2-globin gene was heterozygous for AAG (Lys) and GAG (Glu). This was confirmed by restriction endonuclease digestion with Eco31I.

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