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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 30, 2001 - Issue 4
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Original

ANTIGENICITY OF POLY(I) AND ROS-POLY(I) AND THEIR RECOGNITION OF HUMAN ANTI-DNA AUTOANTIBODIES

Subia Tasneem Department of Biochemistry, Faculty of Medicine, A.M.U., Aligarh, 202002, India
&
Prof. Rashid Ali Department of Biochemistry, Faculty of Medicine, J. N. Medical College, A.M.U., Aligarh, 202002, India; Department of Biochemistry, Faculty of Medicine, A.M.U., Aligarh, 202002, India
Pages 335-345 | Published online: 30 Nov 2001
 
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Abstract

The effect of hydroxyl radicals on polyinosinic acid [poly(I)] was studied. Strand breaks, base alteration and a decrease in absorbance at 248 nm (λmax) were observed upon •OH modification of poly(I). The broad antigen specificity of the induced anti-poly(I) and anti-ROS-poly(I) antibodies showed diverse antigen binding characteristics similar to those of SLE autoantibodies. Recognition of both poly(I) and ROS-poly(I) by human SLE anti-DNA autoantibodies was observed. The possible significance of these findings in the etiology of SLE has been discussed.

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