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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 31, 2002 - Issue 3-4
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INCREASED EXPRESSION OF PHOSPHOLIPASE D1 IN THE SCIATIC NERVE OF RATS WITH EXPERIMENTAL AUTOIMMUNE NEURITIS

T. Shin Department of Veterinary Medicine, Cheju National University, Brain Korea 21, Jeju, 690-756, Republic of Korea
,
D. S. Min Department of Physiology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul, 137-701, Republic of Korea
,
M. Ahn Department of Veterinary Medicine, Cheju National University, Brain Korea 21, Jeju, 690-756, Republic of Korea
,
W. Son Department of Veterinary Medicine, Cheju National University, Brain Korea 21, Jeju, 690-756, Republic of Korea
&
Y. Matsumoto Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, 183, Japan
Pages 169-176 | Published online: 07 Jul 2009
 
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Abstract

Phospholipase D1 (PLD1) expression in the sciatic nerve was studied in induced experimental autoimmune neuritis (EAN) in Lewis rats. PLD1 immunoreactivity was seen in some Schwann cells in the sciatic nerves of normal rats. In parallel with the progression of EAN, PLD1-positive Schwann cells significantly increased in number and showed intense immunoreactivity. PLD1 was also detected in some ED1+ macrophages in EAN lesions. These results suggest that PLD1 in macrophages and Schwann cells plays an important role in the activation of these cells in the pathogenesis of EAN, an animal model of human peripheral demyelinating disease.

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