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Abstract
Objective: To evaluate the relationship between the serum concentration of TNFαRII and some adhesion molecules (including ICAM‐1, VCAM‐1, P‐selectin and E‐selectin) and coronary artery stenosis. Design and setting: Observational (cross‐sectional) study in a university heart hospital in Tehran, Iran. Patients: 81 patients with angiographically proven coronary artery disease were compared with 75 individuals who had undergone coronary angiography with no significant evidence of stenosis (control subjects). Methods: Soluble adhesion molecules and TNFαRII were determined by enzyme‐linked immunosorbent assay technique. sICAM‐1 and sP‐selectin values were significantly higher in patients with coronary artery disease than in control subjects (146 ± 38 vs. 132 ± 48 p < 0.04 and 275 ± 107 vs. 241 ± 104 ng/ml p < 0.04 respectively). Multiple logistic regression analysis showed sICAM‐1 as an independent discriminating risk factor for coronary artery disease (p < 0.03). Prediction models that incorporated sICAM‐1 in addition to other established coronary risk factors were significantly better at predicting risk than the models based on the other risk factors alone. Multiple regression analysis indicated that sP‐selectin levels were greater in patients with single‐vessel disease than in the respective normal (p < 0.01). Conclusions: Our findings suggest that sICAM‐1 has an association with stable coronary artery disease and the evaluation of this marker may improve the coronary risk assessment in Iranian patients.