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Immunopharmacology and Immunotoxicology Volume 27, 2005 - Issue 1
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Research Article

Distinct Cytokine Release Profiles from Human Endothelial and THP-1 Macrophage-like Cells Exposed to Different Amphotericin B Formulations

Lloyd W. Turtinen Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, 54702, USA; Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, WI, 54702, USA
,
Lindsay A. Bremer Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, 54702, USA
,
David N. Prall Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, 54702, USA
,
Jenifer Schwartzhoff Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, 54702, USA
&
Scott C. Hartsel Department of Chemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, 54702, USA
Pages 85-93 | Published online: 08 Oct 2008
 
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Abstract

Amphotericin B(AmB) formulations, Fungizone, and Amphotec caused substantially greater proinflammatory cytokine release than AmBisome (L-AMB) and Abelcet in TPA differentiated THP-1 macrophages as determined by antibody based protein arrays. Lipopolysaccharide but not AmB induced significant pro-inflammatory cytokines in human endothelial cells.

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