Once-Daily Budesonide Inhalation Powder (Pulmicort Turbuhaler®) is Effective and Safe in Adults Previously Treated with Inhaled Corticosteroids

Abstract

This 12-week, double-blind, placebo-controlled, multicenter study evaluated the efficacy and safety of budesonide 400 µg administered once daily via Turbuhaler^TM in adults previously treated with at least twice-daily dosing of inhaled corticosteroids. Pulmonary function (FEV₁, PEF, FVC, FEF_25–75%), asthma symptom scores, quality of life, and breakthrough medication use were significantly (p < 0.05) different in patients receiving once-daily budesonide Turbuhaler compared to placebo, and significantly (0 < 0.001) more patients receiving placebo discontinued the study. Adverse events were similar between study groups. Once-daily administration of budesonide Turbuhaler was safe and efficacious in patients previously treated with inhaled corticosteroids.

• Asthma
• Budesonide
• Inhaled corticosteroid
• Pulmicort Turbu-haler®
• Once-daily
• Dry-powder inhaler