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Abstract
Millimeter wave therapy has been reported to reduce the toxic side effects of chemo- and radiation therapy in the treatment of cancer. In order to understand the mechanisms involved in this reduction, the effect of millimeter electromagnetic waves (MWs) on catalase activity was examined in mouse blood. SKH-1 hairless mice were irradiated on their midbacks with 42.2±0.2 GHz millimeter waves. The incident power density used was 31±5 mW/cm2 and the peak SAR was 622±100 W/kg as measured using infrared thermography. The animals were irradiated before or after administration of cyclophosphamide (CPA), an anticancer drug. The sham control groups were treated in a similar manner, but not irradiated. MW irradiation, before or after administration of CPA did not significantly reduce the toxic effect of CPA on catalase activity in mouse blood.