Myosin Light Chain Phosphorylation Modification Depending on Magnetic Fields. I. Theoretical

Abstract

It is well accepted now that the rapid development of science and technology exposes living nature to a wide range of electromagnetic fields. A series of epidemiological studies has raised concern about possible cancer risk of electromagnetic fields generated by power lines, electrical appliances and cellular communications. In contrast, hundreds of thousands of patients worldwide have been cured by use of electromagnetic fields. Analysis of the biological effects of low-level electromagnetic radiation allows improvement of the therapeutic modalities. However, the problem of accurate and complete dosimetry of the exogenous magnetic or electromagnetic fields remains to be clarified. This article therefore summarizes the theoretical and experimental data obtained by applying cell-free myosin phosphorylation method for screening various, mostly therapeutic, magnetic fields. In addition to searching for an appropriate mechanism of action, the results might provide a new biophysical approach to estimation of exact values of the field parameters at target site as well as the use of cell-free myosin phosphorylation a “method for biophysical dosimetry.” This cell-free system provides an adequate model of biological response in a very small volume (100 µL) which transforms the probe into an effective biological dosimeter. The first of two articles deals with theoretical bases of muscle activity and myosin phosphorylation.

• Magnetic field
• Myosin phosphorylation
• Calmodulin