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Original Articles

STUDY OF DNA INTERACTIONS WITH MELPHALAN, BUSULPHAN, AND ANALOGUES USING AN HPLC METHOD

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Pages 1859-1864 | Received 10 Dec 1999, Accepted 27 Dec 1999, Published online: 06 Feb 2007
 

Abstract

A simple reversed phase HPLC method suitable to study the interactions of alkylating agents with DNA is presented in this paper. DNA interaction is expressed as the % DNA peak size exclusion. The effects caused by the antitumor drugs melphalan, busulphan, and busulpan analogues on DNA were clearly observed through chromatographic data. The synthetic dimethanesulphonates of 2-tetradecyl-1,4-butanediol and 1,2-hexadecanediol were proved more potent than busulphan.

Acknowledgments

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