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Journal of Liquid Chromatography & Related Technologies Volume 23, 2000 - Issue 12
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Original Articles

STUDY OF DNA INTERACTIONS WITH MELPHALAN, BUSULPHAN, AND ANALOGUES USING AN HPLC METHOD

A. Karikas Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens, 15771, Greece
,
V. Constantinou-Kokotou
,
V. Magrioti Laboratory of Chemistry, Agricultural University of Athens, Iera Odos 75, Athens, 11855, Greece
&
G. Kokotos Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens, 15771, Greece
Pages 1859-1864 | Received 10 Dec 1999, Accepted 27 Dec 1999, Published online: 06 Feb 2007
 
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Abstract

A simple reversed phase HPLC method suitable to study the interactions of alkylating agents with DNA is presented in this paper. DNA interaction is expressed as the % DNA peak size exclusion. The effects caused by the antitumor drugs melphalan, busulphan, and busulpan analogues on DNA were clearly observed through chromatographic data. The synthetic dimethanesulphonates of 2-tetradecyl-1,4-butanediol and 1,2-hexadecanediol were proved more potent than busulphan.

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