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Original Articles

SIMULTANEOUS HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF ACETAMINOPHEN, SALICYLAMIDE, PHENYLTOLOXAMINE, AND RELATED PRODUCTS

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Pages 565-578 | Received 01 Nov 1998, Accepted 19 Apr 1999, Published online: 06 Feb 2007
 

Abstract

A stability indicating high performance liquid chromatography method has been developed for simultaneous determination of acetaminophen, salicylamide and phenyltoloxamine. The reversed-phase method utilizes UV detection at 220 nm and a C8 column. This paper presents the data to support linearity, precision, specificity, and robustness of the method. The known potential degradation products of acetaminophen, p-aminophenol, p-nitrophenol, precursor impurity p-hydroxyacetophenone, the potential degradation product of salicylamide, salicylic acid, and precursor impurity ethylsalicylate were separated for quantitation simultaneous with parent compounds. Quantification was achieved by peak area and external standard method. This method can be employed in determining stability, assay, content uniformity, and dissolution of the combination in pharmaceutical dosage forms.

ACKNOWLEDGMENTS

Present address for J. V. A. and U. B. K.: UNMC College of Pharmacy, 600 South 42nd Street, Omaha, NE 68198-6025; Present address for G. V. B.: Western University of Health Sciences, College Plaza, 309 E. Second Street, Pomona, CA 91766–1854.

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