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Journal of Liquid Chromatography & Related Technologies Volume 22, 1999 - Issue 12
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Original Articles

DEVELOPMENT AND VALIDATION OF AN HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF CIS- AND TRANS- PERMETHRIN AND PIPERONYL BUTOXIDE IN PHARMACEUTICAL DOSAGE FORMS

R. Manadas Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, 3000, Portugal
,
F. Veiga Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, 3000, Portugal
,
J. J. Sousa Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, 3000, Portugal
&
M. E. Pina Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, 3000, Portugal
Pages 1867-1876 | Received 15 Aug 1998, Accepted 19 Oct 1998, Published online: 19 Aug 2006
 
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Abstract

A Reversed-Phase High Performance Liquid Chromatographic (RP-HPLC) method for simultaneous and separate determination of cis and trans-permethrin and piperonyl butoxide in a shampoo formulation is described and fully validated. This method entails the quantification of both components by external standard and ultraviolet detection at two wavelengths (201 and 287nm). A C8 Lichrosorb column and a three component mobile phase, isocratically delivered was used.

Results for process validation parameters – selectivity, precision, linearity, and recovery - were in agreement with international specifications. This is a simple method that requires no sample clean up prior to its injection in the system.

Acknowledgments

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