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In order to evaluate tiaprofenic acid in the samples of whole blood, methods of extraction on solid phases (SLE) and those of extraction into an organic solvent (LLE) were worked out and the suitability of its use for HPLC analysis of tiaprofenic acid was compared. SLE was carried out on the solid phases C-18 and LLE into dichloromethane.
Prior to the commencement of extractions, stability of tiaprofenic acid was examined. After the adjustment of the sample by a selected method of extraction (SLE), tiaprofenic acid was evaluated in blood in a two-hour pharmacokinetic study.
Acknowledgments
The work was supported by grant No. 35/1998/B-CH from the Grant Agency of Charles University and by a Research project of Charles University, No. MSM 111600001.