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Journal of Liquid Chromatography & Related Technologies Volume 24, 2001 - Issue 15
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Original Articles

DETERMINATION OF LIPOPHILICITY OF POTENTIAL ANTITUBERCULOUS DRUGS BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

J. Klimeš Department of Pharmaceutical Chemistry and Drug Control, Charles University, Hradec Králové, 500 05, Czech RepublicCorrespondence[email protected]
,
G. Zimová Department of Pharmaceutical Chemistry and Drug Control, Charles University, Hradec Králové, 500 05, Czech Republic
,
P. Kastner Department of Pharmaceutical Chemistry and Drug Control, Charles University, Hradec Králové, 500 05, Czech Republic
,
V. Klimešová Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, 500 05, Czech Republic
&
K. Palát Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, 500 05, Czech Republic
Pages 2257-2265 | Received 01 Jan 2001, Accepted 26 Jan 2001, Published online: 06 Feb 2007
 
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Abstract

The RP-HPLC capacity factors k of two series of 4-benzylthio-derivatives, newly synthetised as potential antituberculous drugs, were determined on two types of C18 columns with methanol–water as the mobile phase, using UV detection. The measured log k values were compared with the log P values obtained by means of mathematical programmes and methods. High correlation was found between log P and log k values.

ACKNOWLEDGMENTS

This work was supported by the Grant Agency of Charles University (grant No. 237/2000 BCH/FaF).

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