Abstract
A quantitative method using silica gel HPTLC plates with fluorescent indicator, automated sample application, and UV absorption densitometry of the fluorescence quenching zones was developed for the determination of meclizine hydrochloride in motion sickness tablets. Samples of three brands of tablets assayed within 97.0–110% of the 25 mg label value. Precision (relative standard deviation) was 1.58 and 1.26% for replicate analyses of two tablets. The error of a standard addition analysis performed to evaluate accuracy was 0.506%. These validation data are within the guidelines of the International Conference on Harmonization for pharmaceutical analysis.