![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
A new ligand exchange chromatography (LEC) packing material consisting of L-proline modified urea-formaldehyde resin microspheres was prepared and tested. The experiments show that the material has a good enantioselectivity for the chiral separation of amino acid racemates. Solvent acetonitrile and high column temperature are favorable for enhancing the selectivity. There is an optimal ammonia concentration in the eluent for the LEC separation. Among the 17 DL-amino acids separated, 16 have the D-eluted ahead of the L-enantiomers, except for proline.
ACKNOWLEDGMENT
The authors are grateful to NSFC for the grant 29635010.