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Journal of Liquid Chromatography & Related Technologies Volume 25, 2002 - Issue 18
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Original Articles

LIPOPHILICITY CHARACTERIZATION BY REVERSED-PHASE HPLC OF POTENTIAL ANTITUBERCULOTICS

Petr Kastner Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskho 1203, Hradec Kralove, 500 05, Czech RepublicCorrespondence[email protected]
,
Jiri Klimes Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskho 1203, Hradec Kralove, 500 05, Czech Republic
,
Petra Velenovska Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskho 1203, Hradec Kralove, 500 05, Czech Republic
&
Vera Klimesova Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskho 1203, Hradec Kralove, 500 05, Czech Republic
Pages 2849-2856 | Received 15 Apr 2002, Accepted 25 May 2002, Published online: 19 Aug 2006
 
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ABSTRACT

Lipophilicity is one of the properties which influence the partition of a substance in biological media. The reversed-phase high-performance liquid chromatographic (RP-HPLC) capacity factors k of two series of 2-benzylthioderivatives, newly synthesized as potential antituberculous drugs, were determined on a C-18 stationary phase with methanol–water as the mobile phase, using UV detection. The measured log k values were compared with the log P values obtained by means of a mathematical method. High correlation was found between log P and log k values.

ACKNOWLEDGMENTS

This work was supported by the Grant Agency of Charles University (grant No. 237/2000 BCH/Faf) and Grant MSM 111600001.

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