32
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

PHOTODEGRADATION KINETIC STUDIES AND STABILITY-INDICATING ASSAY OF DILOXANIDE FUROATE IN DOSAGE FORMS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

Pages 2974-2964 | Received 17 Feb 2002, Accepted 20 Jun 2002, Published online: 06 Feb 2007
 

ABSTRACT

The effect of different conditions on the photostability of diloxanide furoate (DF) was investigated. To perform stability studies on DF, a specific stability-indicating high-performance liquid chromatographic (HPLC) method was established using an ultraviolet detector set at 258 nm. The accuracy, precision, and reliability of the method for the assay of DF in its tablets dosage form were established. Assay results were within RSD values less than 2%. The stability-indicating power of the HPLC method was validated by UV-degraded DF solution in a mixture of acetonitrile:water (55 : 45 v/v) contained in quartz cells and glass bottles. The resultant chromatogram indicated that the degradation products were well separated from the parent drug. Photostability of DF was studied under different light exposures, i.e., UV-irradiation, room artificial light, and sunlight. Using the HPLC method, the photodegradation kinetics of the drug was studied in both a quartz cell and glass bottle. In both cases the photodegradation process followed first-order kinetics. The effects of different solvents on the UV-irradiation of DF are also reported. One of the three major degradation products observed was identified.

Acknowledgments

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 583.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.