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Journal of Liquid Chromatography & Related Technologies Volume 26, 2003 - Issue 3
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Original Articles

Purification of HTOS Libraries by Supercritical Fluid Chromatography

Jill Hochlowski Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USACorrespondence[email protected]
,
Jeff Olson Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA
,
Jeff Pan Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA
,
Daryl Sauer Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA
,
Philip Searle Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA
&
Thomas Sowin Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA
Pages 333-354 | Received 02 Sep 2002, Accepted 30 Sep 2002, Published online: 24 Jun 2011
 
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Abstract

A commercially available preparative scale supercritical fluid chromatography (SFC) system has been customized and applied to the purification of high throughput organic synthesis (HTOS) libraries. Pilot reactions allow the triage between HPLC and SFC as the most appropriate purification technique, and when applicable, SFC has been proven to offer advantages in terms of decreased purification and sample dry‐down time and purification capabilities, somewhat complementary to HPLC. Standardized chemistry‐specific SFC methods have been determined and HTOS pilot reactions allow refinement of these standard methods to optimal conditions for a specific library core.

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