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Journal of Liquid Chromatography & Related Technologies Volume 26, 2003 - Issue 7
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Original Articles

HPLC Determination of Flunarizine Dihydrochloride in Tablets and Its Validation

Wiwin Farina Kartinasari Quality Control Laboratory, Bernofarm Pharmaceutical Company, Buduran, Sidoarjo, Surabaya, Indonesia
,
Henny Chufianty Quality Control Laboratory, Bernofarm Pharmaceutical Company, Buduran, Sidoarjo, Surabaya, Indonesia
&
Gunawan Indrayanto Department of Natural Product, Faculty of Pharmacy, Airlangga State University, Jl. Dharmawangsa dalam, Surabaya, 60286, IndonesiaCorrespondence[email protected]
Pages 1059-1067 | Received 30 Oct 2002, Accepted 02 Dec 2002, Published online: 24 Jun 2011
 
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Abstract

A simple, rapid, and validated HPLC method has been developed for determination of flunarizine dihydrochloride in the tablet preparations. A LiChrospher 100 RP‐18 column was used with a mobile phase consisting of methanol–ion pair solution, 8 + 2, v/v. Quantitative evaluation was performed at 254 nm. The HPLC method is selective, precise, and accurate and can be used for routine analysis of the tablet preparations in pharmaceutical industry quality control laboratories.

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