Automatic Selection of Mobile Phases. III. TLC on Silica of 2,3,4‐Trisubstituted Tetrahydroisoquinolinones

Abstract

New, successful application of the LSChrom software, incorporating the Snyder theory to complex organic compounds is performed. This permitted an automatic selection, without any preliminary attempts, of suitable mobile phases for thin‐layer chromatography (TLC), on silica, of trans‐2‐phenethyl‐3‐(1‐methyl‐1H‐pyrrol‐2‐yl)‐4‐substituted‐1,2,3,4‐tetrahydroisoquinolin‐1‐ones. The automatic selection of the mobile phases is based on the structure of any compound, literature data for the adsorption properties of the relevant structural fragments (groups) available in the structure and a many calculations.

Keywords:

• Normal‐phase liquid‐solid chromatography
• Silica
• Nitrogen heterocycles
• Mobile‐phase selection
• Snyder theory in LSChrom software