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Abstract
A series of 13 5,5‐disubstituted derivatives of barbituric acid was chromatographed on RP‐TLC plates using methanol:water and methanol:buffer mobile phase. A linear relationship was found between R M values and methanol concentrations in the mobile phase. The retention parameter R M0 extrapolated to zero methanol content was related to other lipophilicity parameters such as log k IAM, log P (calculated), selected biological activity values, and topological indices. Significant correlations were found between these parameters.