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Abstract
A micellar liquid chromatographic method for quality control of pharmaceutical preparations (capsules, pills, tablets, injections, drops, and suppositories) containing the anticonvulsant drugs acetazolamide, carbamacepine, chlordiazepoxide, diazepam, ethosuximide, phenytoin, phenobarbital, and zopiclone has been developed. This methodology involves the use of micellar solutions of cetyltrimethylammonium bromide (CTAB) as mobile phases and UV detection. The proposed approach is rapid and reproducible. Sample preparation only requires dissolution with micellar solvent and adequate dilution with the mobile phase before injection into the chromatographic system.
Acknowledgments
The authors acknowledge the Spanish Ministry of Science and Technology (MCYT) and the European Regional Development Fund (ERDF) for the financial support (project SAF2002‐01330). J. J. Martínez‐Pla is also grateful to the Spanish Ministry of Education and Culture for the FPU grant (ref. FPU‐AP99).