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Journal of Liquid Chromatography & Related Technologies Volume 27, 2004 - Issue 16
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Original Articles

Reversed‐Phase High Performance Liquid Chromatographic Determination of Lipophilicity of Potential Antituberculosis Compounds

Jan Kresta Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, CZ‐50005, Hradec Králové, Czech RepublicCorrespondence[email protected]
,
Petr Kastner Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, CZ‐50005, Hradec Králové, Czech Republic
,
Jiri Klimeš Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, CZ‐50005, Hradec Králové, Czech Republic
&
Věra Klimešová Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, CZ‐50005, Hradec Králové, Czech Republic
Pages 2539-2545 | Received 30 Mar 2004, Accepted 27 Apr 2004, Published online: 11 Jun 2009
 
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Abstract

Lipophilicity is one of the properties, which influences the partition of a substance in biological media. The reversed‐phase high performance liquid chromatography (RP‐HPLC) capacity factors k of 27 2‐benzylsulfanyl derivatives of benzothiazole, newly synthesized as potential antituberculous drugs, were determined on a C18 stationary phase with methanol–water as the mobile phase, using UV detection. The measured log k values were compared with the log P values obtained by means of mathematical methods. High correlation was found between log P and log k values.

Acknowledgment

This work was supported by the Ministry of Education of the Czech Republic (Research Plans No. 111600001).

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